Which Staphylococcus species, besides Staphylococcus aureus, also produces coagulase?

Staphylococcus intermedius is recognized for its ability to produce coagulase, similar to Staphylococcus aureus. This species is often isolated from animals and can occasionally infect humans, particularly in cases involving animal bites or exposure. Coagulase is an enzyme that causes blood plasma to clot, which plays a role in the pathogenicity of certain staphylococcal species; it is particularly associated with virulence.

Staphylococcus saprophyticus and Staphylococcus hominis do not produce coagulase. S. saprophyticus is known for causing urinary tract infections and is characterized as coagulase-negative, while S. hominis is considered part of the skin flora and is also coagulase-negative. This understanding highlights the distinction between coagulase-positive and coagulase-negative staphylococci, which is crucial in clinical microbiology for identifying pathogenic species.