Which first-line antibiotics are used to treat classic tuberculosis and tested by disk diffusion method?

The first-line antibiotics used to treat classic tuberculosis include isonicotinic acid hydrazide (INH), rifampin, ethambutol, and pyrazinamide. These agents are specifically designed to target Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, with a focus on effectively reducing the bacterial load and preventing the emergence of drug resistance.

The reason these antibiotics are relevant for disk diffusion testing is that they are well-established in clinical practice for their efficacy against tuberculosis and are included in standard treatment guidelines. The disk diffusion method assesses the susceptibility of bacteria to these antibiotics by measuring zones of inhibition where bacterial growth is prevented around antibiotic-impregnated disks.

This approach allows for determining which antibiotics can effectively treat a patient's infection based on the sensitivity profile of the Mycobacterium tuberculosis strain, ensuring that patients receive appropriate therapy to optimize treatment outcomes. The other options listed involve antibiotics that are not typically used as first-line agents for tuberculosis treatment and are not monitored by the disk diffusion method for this specific purpose.