Which Enterobacteriaceae genus is typically resistant to colistin?

Proteus is the genus within the Enterobacteriaceae family that is typically associated with resistance to colistin. This resistance can arise due to various mechanisms, including alterations in the outer membrane that prevent colistin from binding effectively to the bacterial cell wall, as well as the presence of specific resistance genes that can confer a survival advantage under antibiotic pressure.

Colistin is an antibiotic that is often used as a last resort for multidrug-resistant Gram-negative infections, and understanding which genera have shown resistance is crucial for effective treatment options. In clinical settings, the observation of resistance among Proteus species has been documented, signaling the need for monitoring and susceptibility testing to guide appropriate antibacterial therapy, especially in the case of serious infections caused by multidrug-resistant organisms. This knowledge is essential for healthcare professionals to tailor their treatment strategies effectively.